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🥑 Make smarter food choices. Become a member at http://zoe.com Think weight loss is all about eating less and moving more? Think again. In this episode, Dr. Giles Yeo reveals why calorie counting isn’t just inaccurate—it could actually make weight management harder. He explains why the popular “calories in, calories out” method doesn’t add up and explores how factors like genetics, brain signals, and gut health play a major role in shaping our weight. Giles Yeo is a Professor of Molecular Neuroendocrinology at the University of Cambridge and Honorary President of the British Dietetic Association. His research focuses on the influence of genes on feeding behaviour and body weight. Giles is also the author of ‘Gene Eating’ and ‘Why Calories Don’t Count’. Giles shares the surprising impact of ultra-processed foods on how we process calories and why losing weight often feels like a battle against our own biology. With decades of research in his back pocket, Giles shares science-backed advice to help you break free from yo-yo dieting, read calorie labels smarter, and embrace a more balanced, plant-rich diet for long-term health. 🌱 Try our new plant based wholefood supplement - Daily30: https://zoe.com/daily30?utm_medium=zo... *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system Follow ZOE on Instagram | / zoe Timecodes 00:00 Giles Yeo explains why calorie counting is nutrient blind 01:10 Introduction to Professor Giles Yeo 02:23 The biggest myth about weight management 03:30 What are calories? Understanding their origins and purpose 05:10 The science of Atwater’s method: Measuring energy in food 07:20 Burning poop: How calorie absorption was calculated 09:50 How calorie labels influence our understanding of weight 12:30 The invention of calorie counting 15:10 How calorie counting became weaponized in diet culture 18:30 Why calorie counting overlooks the importance of food quality 22:00 The science of appetite: Hunger, fullness, and reward 26:10 Stress and eating: Why some people overeat and others stop 30:00 Dessert stomachs and why we crave high-energy foods 34:10 How ultra-processed food make you eat more 38:50 How gut hormones influence hunger and fullness 43:00 Why fat and carbs light up our brains 47:20 Why natural foods rarely combine fat and carbs 51:00 Ultra-processed foods: Are they all bad? 55:00 3 numbers for better health: Protein, fiber, and sugar 59:50 Final thoughts on improving diet and managing weight 📚Books by our ZOE Scientists The Food For Life Cookbook | https://amzn.to/4amfIMX Every Body Should Know This by Dr Federica Amati | https://amzn.to/4blJsLg Food For Life by Prof. Tim Spector | https://amzn.to/4amZinu Free resources from ZOE: Live Healthier: Top 10 Tips From ZOE Science & Nutrition | https://zoe.com/freeguide Gut Guide - For a Healthier Microbiome in Weeks | https://zoe.com/gutguide Mentioned in today's episode Long-term weight-loss maintenance: a meta-analysis of US studies, 2001, published in American Journal of Clinical Nutrition https://pubmed.ncbi.nlm.nih.gov/11684... How dieting might make some fatter: modeling weight cycling toward obesity from a perspective of body composition autoregulation, 2020, published in International Journal of Obesity https://www.nature.com/articles/s4136... Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up, 2007, published in Journal of the American Dietetic Association https://pubmed.ncbi.nlm.nih.gov/17904... Diet or Exercise Interventions vs Combined Behavioral Weight Management Programs: A Systematic Review and Meta-Analysis of Direct Comparisons, 2014, published in Journal of the Academy of Nutrition and Dietetics https://www.ncbi.nlm.nih.gov/pmc/arti... Diet, exercise or diet with exercise: comparing the effectiveness of treatment options for weight-loss and changes in fitness for adults (18–65 years old) who are overfat, or obese; systematic review and meta-analysis, 2015, published in Journal of Diabetes & Metabolic Disorders https://link.springer.com/article/10.... Is regular exercise an effective strategy for weight loss maintenance?, 2019, Physiology & Behavior https://www.ncbi.nlm.nih.gov/pmc/arti... Have feedback or a topic you'd like us to cover? Let us know here: https://gf6hx47iu5g.typeform.com/topi... Episode transcripts are available here: https://zoe.com/learn/category/podcasts