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Systems Biology of Disease Progression 10 лет назад


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Systems Biology of Disease Progression

ADAPT (Analysis of Dynamic Adaptations in Parameter Trajectories) is a modeling approach to simulate the progression of metabolic diseases. The method, originally developed at the Eindhoven University of Technology, can also be applied to evaluate the long-term effects of pharmacological interventions. Using a Systems Biology approach, experimental data from longitudinal studies are integrated in mechanism-based disease progression models. ADAPT identifies the biological processes that are disturbed and collectively induce the disease. Such information can be used for the development of therapies, improved diagnosis and prevention. For more information, see: C.A. Tiemann, J. Vanlier, M.H. Oosterveer, A.K. Groen, P.A.J. Hilbers, N.A.W. van Riel, Parameter trajectory analysis to identify treatment effects of pharmacological interventions, PLoS Comput. Biol. 2013, 9(8), e1003166 (http://dx.doi.org/10.1371/journal.pcb.... Acknowledgement: This research was funded by the Netherlands Consortium for Systems Biology and the European Union, FP7-HEALTH (nr. 305707, RESOLVE). Credits: Animation: ICMS Animation Studio Voice-over: Studio Make Music: "Nebulas Night" by Jason Livesay

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