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Mechanism of Alternative Splicing in Cancer Therapy

Mechanism of Alternative Splicing in Cancer Therapy Alternative splicing is an important process that leads to the production of multiple proteins from a single gene by the rearrangement of exons and introns. It is one of the main drivers of proteome diversity. The spliceosome is the macromolecular machinery that mediates the process of alternative splicing through a multi-step process involving sequential binding and release of small nuclear ribonuclear protein (snRNP). Alternative splicing is a complex process that is tightly regulated by SR proteins, hnRNPs and several splicing factors. Aberration in alternative splicing patterns is associated with several diseases including cancer. By modulating alternative splicing, the course of a disease may be altered or prevented. This review focuses on the role of alternative splicing in cancer development, the alteration of splicing factors in cancer, small molecules that inhibit splicing, targeting splicing regulators and the use of oligonucleotides that can be employed as potential therapeutic strategies in cancer therapy. #Alternative_splicing #cancer #genes #splicingfactor #modulate Please see the book here https://bp.bookpi.org/index.php/bpi/c...