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http://www.DoctorsToTrust.com @doctorstotrust presents episode 2704 | Dr BEN BIKMAN w/ Metabolic Classroom Cortisol affects the brain: influences appetite and food craving… -especially for carbs Cortisol crosses the blood brain barrier, binding to glucocorticoid receptors in hypothalamus and amygdula— both involved in hunger and reward In hypothalamus, it upregulates protein NPY and AGRP--which stimulate appetite At same time: cortisol inhibits leptin— reducing satiety In amygdula, cortisol enhances dopamine release… -increasing cravings for high energy foods—carbs Study 2017, higher cortisol levels predicted increased cravings for carbs and starches over six months Study, 2019, food cue-induced cortisol correlated with craving carb-rich foods Study 2016, higher cortisol correlated with increased cravings for sweet & savory carb-rich foods--decreased as cortisol levels were fixed People with Cushings Disease, with high cortisol, had much more cravings for carb-rich foods, but when cortisol levels were down, so too were the cravings As cortisol goes high, crave more carb-rich foods—spiking blood glucose higher; And, as eating carbs spikes insulin --that drives IR Besides the high cortisol itself pushing insulin up, causing IR and weight gain Summary cortisol is a multifaceted hormone that, when chronically elevated, will profoundly affect metabolism -promotes gluconeogenesis by activating enzymes like, PEPCK, gluco 6 phosphatase -causing hyerglycemia and IR Causing dramatic climb in T2D rates Summary pathogenic changes in pathways that shape how we grow fat… -strong influence on storing fat in visceral, trunk area of body -at expense of healthy fat storage in subcutaneous fat Cortisol's action on fat must have sufficient insulin too Chronically high cortisol affects the brain: driving cravings for carbs & starches leading to weight gain Cortisol is essential for mobilizing energy |||||||||||||||||||||||||||||||| doctorstotrust.com benbikman.com insuliniq.com hlthcode.com gethlth.com original video here: • 98: Cortisol & Insulin Resistance: Ho... We do not use corruptible, epidemiological survey research as causal science. For each short/sharable video, the original Youtube links are provided above. None of this content is intended to be individual, personalized medical advice. We hope you find value for yourself in these videos & find them easy to share with loved ones! DISCLAIMER The DoctorsToTrust videos are for general informational purposes only and do not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.