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Garry Tan of Y Combinator: How Innovation Is Changing

Y Combinator has long been - and continues to be - the tip of the innovation spear. That's why I was especially excited to sit down with Garry Tan, President & CEO of Y Combinator, for a conversation that gets right to the core of what’s changing across the startup landscape. At Interplay, I've spent years working alongside entrepreneurs who are laser-focused on building, scaling, and making a lasting impact. Over that time, I've seen countless trends come and go - but when a true seismic shift hits, like the one we’re seeing with AI today, it’s critical to step back and understand the bigger picture. Garry and I dove deep into why vertical SaaS and AI-native startups are poised to drive the next wave of innovation, how lean, AI-augmented teams are rewriting the rules of company building, and why real traction still comes down to solving tangible user problems. We also explored the geographic shifts reshaping where startups thrive, the current realities of AI adoption, and what it truly takes to build a product the world actually wants. It’s a great, timely conversation. A special thanks to Garry for joining me and sharing his insights. 00:00 – Introduction: Why Garry Tan and Y Combinator Matter 00:48 – Garry Tan Joins the Conversation 02:00 – Trends at the Top of the Startup Funnel 02:45 – The Rise of AI and Vertical SaaS Opportunities 04:00 – Leaner Startups: Building Companies with Smaller Teams 05:00 – How AI is Reshaping Company Growth and Scaling 06:00 – Internal Use of AI: Operational Efficiency Across Startups 07:30 – Early Innings: The Long-Term Impact of AI 09:00 – Mainstream AI Adoption: How Far We Have to Go 10:00 – Geography Trends: Where Startup Hubs Are Emerging 11:00 – Why San Francisco Still Matters for Founders 12:30 – The Golden Age of Startups: What's Next 13:30 – Critical Skills for Founders in the AI Era 14:00 – The #1 Reason Startups Fail: Solving Real User Problems 14:30 – Closing Thoughts: Building the Future of Innovation Links: Garry Tan LinkedIn:   / garrytan   Y Combinator Website: https://www.ycombinator.com/ Interplay Website: https://www.interplay.vc/ MPD X: https://x.com/mpd