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Phacilitate:TALKS - The Next Generation of Gene Therapy

Jessica compares the gene therapy industry to the poem ‘A Road Less Travelled’, in that the industry isn’t entirely untrodden but the track is rough and hard to follow. Although, that doesn’t mean we shouldn’t take it. This episode was delivered in a context of being second to market, where the first product is not ‘best in class’ and the room for innovation and improvement is vast. Jessica takes us through the gene therapy toolbox (viral vectors, poration technologies, gene editing tools, exosomes) to consider what’s viable, scalable and where the big potential lies, most notably, the CRISPR-mediated delivery of a CAR by electroporation. This innovation is having an impact. The rate of products entering the clinic is matched only by the rate of investment in the sector. A clear example of this is CRISPR, Elizabeth Charpentier and Jennifer Doudna’s paper was published in 2012 and by 2015 it was a $1bn industry. Watch this episode of Phacilitate:TALKS to find out more about Jessica’s take on the next generation of gene therapy…