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Autophagy: Mechanism, Regulation and Importance of Autophagy in Clinical Medicine

This video explains about Autophagy: Mechanism of Autophagy, Regulation of Autophagy and the Importance of Autophagy in Clinical Medicine. Autophagy is derived from the Greek word, Auto meaning “Self” and phagein meaning “to eat”. Autophagy is a highly conserved pathway that degrades cellular components, such as defective organelles and aggregates of misfolded protein, through lysosomes.  Autophagic process is meant for regulating diverse cellular functions including: 1. Growth, 2. Differentiation, 3. Response to nutrient deficit and oxidative stress, 4. Cell death, and 5. Macromolecule and organelle turnover. Types of Autophagy: 1. Macroautophagy 2. Microautophagy 3. Charperon Mediated Autophagy Discussion about Autophagy Inducers and Inhibitors and Autophagy as a Double Edged Sword. Reference Articles: Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy Valdenizia R. Silva, Sara P. Neves, Luciano de S. Santos, Rosane B. Dias and Daniel P. Bezerra An Overview of Autophagy: Morphology, Mechanism, and Regulation Katherine R. Parzych and Daniel J. Klionsky An overview of autophagy: Mechanism, regulation and research progress Weiya Cao, Jinhong Li, Kepeng Yang, Dongli Cao AutophagyMechanism, Regulation, Functions, and Disorders Mallikarjun Badadani Clinical Applications of Autophagy Feature Autophagy as a double-edged sword https://www.med.uio.no/cancell/englis... Research Papers: Yoshinori Ohsumi Autophagy in Yeast Demonstrated with Proteinase-deficient Mutants and Conditions for its Induction Kazuhiko Takeshige, Misuzu Baba, Shigeru Tsuboi, Takeshi Noda, and Yoshinori Ohsumi Isofation and charact~~zation of autophagy-defective mutants of Saccharomyces cerevisiae Miki Tsukada, Yoshinori Ohsumi A protein conjugation system essential for autophagy Noboru Mizushima, Takeshi Noda, Tamotsu Yoshimori, Yae Tanaka, Tomoko Ishii†, Michael D. George, Daniel J. Klionsky, Mariko Ohsumi† & Yoshinori Ohsumi A ubiquitin-like system mediates protein lipidation Yoshinobu Ichimura, Takayoshi Kirisako*²³, Toshifumi Takao§, Yoshinori Satomi§, Yasutsugu Shimonishi§, Naotada Ishihara, Noboru Mizushima k, Isei Tanida, Eiki Kominami¶, Mariko Ohsumi#, Takeshi Noda*² & Yoshinori Ohsumi Related Videos: --------------------------------------------------------------------------------------------------------------- Plotting Bacterial Growth Curve:    • Plotting Bacterial Growth Curve in Excel   Colony Forming Units:    • CFU: Colony Forming Unit & cfu/ml calculation   Serial Dilution Methods:    • Serial Dilution Methods & Calaculations   Copy Number Calculation for qPCR:    • Copy Number Calculation for qPCR   How to analyze Primer Sequence or Oligonucleotide sequence designed for PCR / qPCR:    • How to analyze Primer Sequence or Oligonuc...   How to generate qPCR standard curve in excel and calculate PCR efficiency:    • How to generate qPCR standard curve in exc...   Real Time qPCR optimization, Calculating PCR Efficiency:    • Real Time qPCR  optimization, Calculating ...   Taqman Assay Vs SYBR Green Assay:    • Real Time PCR Assays- Taqman Assay Vs SYBR...   Resolving poor PCR efficiency:    • Resolving Poor PCR assay Efficiency in Rea...   Calculating molecular weight of Unknown protein    • How to calculate molecular weight of unkno...   Designing qPCR Primers    • Primer designing for real time PCR using N...   Oligonucleotide Preparation & Purification    • Oligonucleotide Preparation and Purificati...   How to check Oligo Concentration    • How to check the Oligo concentration or Pr...