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Single-molecule dynamics and interactions of disordered proteins - Ben Schuler - NGBS2024

Single-molecule dynamics and interactions of disordered proteins: from disordered complexes to phase separation Speaker: Ben Schuler, University of Zurich, Switzerland Chair: David Rueda, Imperial College, London/MRC-LMS, UK Co-Chair: Christopher Batters, MRC Laboratory of Molecular Biology, UK Ben Schuler describes his work on understanding the function of intrinsically disordered proteins. He shows how different single molecule techniques are needed to access the timescales from protein chain dynamics to folding and binding. He illustrates this by using the example histone H1 and its chaperone ProthymosinAlpha (ProTAlpha) which are both highly charged and are largely intrinsically disordered. He shows that while they interact with high affinity, they are both highly dynamic which allows rapid association and dissociation. This reveals how ProTAlpha can function to remove H1 from nucleosomes. In the second part of his talk, he demonstrations how experimental and large scale coarse-grained molecular dynamic simulations can reveal the dynamics of the interactions between these proteins when they phase separate into coacervates. This has allowed him to construct a phase diagram for the two proteins from monomers through heterodimers to coacervates. Read more about Ben Schuler’s work here: https://schuler.bioc.uzh.ch/ You can find more about the Next Generation Biophysics Symposium 2024 here: https://www3.mrc-lmb.cam.ac.uk/sites/... -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook:   / mrc.lmb   X/Twitter:   / mrc_lmb   Instagram:   / mrc_lmb   LinkedIn:   / mrc-laboratory-of-molecular-biology   Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...