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The Hallmarks of Aging: Cellular senescence | LifeXtenShow

Believe it or not, there probably are zombie cells in your body right now, and they’re helping to stage one of the scariest molecular biology horror movies: aging. Thanks to Kali Carrigan for writing the script! Liked the show? Let us know on Twitter at   / lifespanio   or our Discord server at   / discord   Facebook:   / lifespanio   LinkedIn:   / lifespanio   Instagram:   / lifespan.io   Website: https://www.leafscience.org/ Stock contents: Shutterstock, Videoblocks Music: Intro jingle courtesy of Kevin MacLeod - Incompetech.com Crumbling rocks sound effect: Opsaaaaa (freesound.org) -------------------------- Sources: López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217. Baar, M. P., Brandt, R. M., Putavet, D. A., Klein, J. D., Derks, K. W., Bourgeois, B. R., ... & van der Pluijm, I. (2017). Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell, 169(1), 132-147. Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018). Hallmarks of Cellular Senescence. Trends in Cell Biology, 28(6), 436–453. doi:10.1016/j.tcb.2018.02.001 Collado, M., Blasco, M. A., & Serrano, M. (2007). Cellular senescence in cancer and aging. Cell, 130(2), 223-233. Campisi, J. (2001). Cellular senescence as a tumor-suppressor mechanism. Trends in cell biology, 11(11), S27-S31. Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., ... & Hoeijmakers, J. H. (2014). An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental cell, 31(6), 722-733. Hickson, L. J., Prata, L. G. L., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., ... & Kellogg, T. A. (2019). Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease. EBioMedicine, 47, 446-456. Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M., & Kirkland, J. L. (2015). Cellular senescence in type 2 diabetes: a therapeutic opportunity. Diabetes, 64(7), 2289-2298. Tominaga, K. (2015). The emerging role of senescent cells in tissue homeostasis and pathophysiology. Pathobiology of Aging & Age-Related Diseases, 5(1), 27743. Tonnessen-Murray, C. A., Frey, W. D., Rao, S. G., Shahbandi, A., Ungerleider, N. A., Olayiwola, J. O., ... & Jackson, J. G. (2019). Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival. Journal of Cell Biology, 218(11), 3827-3844. Van Deursen, J. M. (2014). The role of senescent cells in ageing. Nature, 509(7501), 439. Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., … van Deursen, J. M. (2011). Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature, 479(7372), 232–236. Wang, Y., Chang, J., Liu, X., Zhang, X., Zhang, S., Zhang, X., ... & Zheng, G. (2016). Discovery of piperlongumine as a potential novel lead for the development of senolytic agents. Aging (Albany NY), 8(11), 2915. White, R. R., & Vijg, J. (2016). Do DNA double-strand breaks drive aging?. Molecular cell, 63(5), 729-738. . Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., ... & McGuckian, C. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18-28. Zhu, Y., Armstrong, J. L., Tchkonia, T., & Kirkland, J. L. (2014). Cellular senescence and the senescent secretory phenotype in age-related chronic diseases. Current Opinion in Clinical Nutrition & Metabolic Care, 17(4), 324-328. Rao, S. G., & Jackson, J. G. (2016). SASP: Tumor Suppressor or Promoter? Yes! Trends in Cancer, 2(11), 676–687. doi:10.1016/j.trecan.2016.10.001 Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., ... & Kirkland, J. L. (2019). Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine, 40, 554-563. Nyunoya, T., Monick, M. M., Klingelhutz, A., Yarovinsky, T. O., Cagley, J. R., & Hunninghake, G. W. (2006). Cigarette smoke induces cellular senescence. American journal of respiratory cell and molecular biology, 35(6), 681-688. Debacq-Chainiaux, F., Leduc, C., Verbeke, A., & Toussaint, O. (2012). UV, stress and aging. Dermato-endocrinology, 4(3), 236-240. -------------------------- #SenescentCells #CellularSenescence #Senolytics #ZombieCells #Zombies #Aging #LifeExtension #Biology #MolecularBiology