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Cell Adhesion Molecules: Cadherin, Selectin, IgSF, Integrin | CELL BIOLOGY CSIR NET Lifescience

Cell Adhesion Molecules (CAM): Cadherin, Selectin, IgSF, Integrin Cell adhesion molecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular matrix (ECM), in a process called cell adhesion. In essence, CAMs help cells stick to each other and to their surroundings. CAMs are crucial components in maintaining tissue structure and function. In fully developed animals, these molecules play an integral role in generating force and movement and consequently ensuring that organs are able to execute their functions normally. CAMs are typically single-pass transmembrane receptors and are composed of three conserved domains: an intracellular domain that interacts with the cytoskeleton, a transmembrane domain, and an extracellular domain. These proteins can interact in several different ways. The first method is through homophilic binding, where CAMs bind with the same CAMs. They are also capable of heterophilic binding, meaning a CAM on one cell will bind with different CAMs on another cell. Immunoglobulin superfamily CAMs (IgSF CAMs) is regarded as the most diverse superfamily of CAMs. This family is characterized by their extracellular domains containing Ig-like domains. Integrins, one of the major classes of receptors within the ECM,mediates cell–ECM interactions with collagen, fibrinogen, fibronectin, and vitronectin. Integrins provide essential links between the extracellular environment and the intracellular signalling pathways, which can play roles in cell behaviours such as apoptosis, differentiation, survival, and transcription. The cadherins are homophilic Ca2+ dependent glycoproteins. The classic cadherins (E-, N and P-) are concentrated at the intermediate cell junctions, which link to the actin filament network through specific linking proteins called catenins. The selectins are a family of heterophilic CAMs that are dependent on fucosylated carbohydrates, e.g., mucins for binding. The three family members are E-selectin (endothelial), L-selectin (leukocyte), and P-selectin (platelet). 0:30 Cell adhesion molecules 3:00 Homophilic and Heterophilic interaction 5:06 Different types of CAMs 5:33 Cadherin 15:13 IgSF 19:21 Selectin 22: 31 Integrin ➖➖➖➖➖➖➖➖➖➖➖➖ Any doubts regarding this topic? Feel free to comment here below. ➖➖➖➖➖➖➖➖➖➖➖➖ If you like this video and find it useful Please Support me with your LIKES, SUBSCRIBE to this channel and SHARE with your friends SUBSCRIBE: https://bit.ly/34qhQVG ➖➖➖➖➖➖➖➖➖➖➖➖ Telegram channel : https://t.me/BioVidyalaya Facebook:   / biovidyalaya   ➖➖➖➖➖➖➖➖➖➖➖➖ ©NOTE : Some Images, Graphics, are shown​ in this video May be Copyrighted to respected owners. ➖➖➖➖➖➖➖➖➖➖➖➖ KEEP WATCHING... THANK YOU FOR THE SUPPORT Chithra #csirnet2022 | #BioVidyalaya | #cellbiology cell biology part b csir net, csir net cell biology, csir net cell biology topics, cell biology, cell adhesion, cell adhesion molecules, cadherin in cell adhesion, imtegrin function, selectin binding, icam, vcam, n cam, csir ugc net 2022, cell biology for jrf exam, CSIR NET Life Sciences preparation csir net life science lecture in english CSIR NET lifescience unit 2 csir net life science cell biology notes for csir net CSIR net lifescience class in english CSIR net life science free lecture videos life science lectures free CSIR net life science best youtube channel CSIR net lifescience concept Biology channel Biovidyalaya by chithra