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Ajit Varki provides an overview preceding the discussion on "How are Humans Different from Other Great Apes?" The event was co-hosted by CARTA, the UCSD/Salk Center for Academic Research and Training in Anthropogeny. Ajit Varki is Distinguished Professor of Medicine and Cellular & Molecular Medicine, Co-Director of the Glycobiology Research and Training Center (GRTC), Executive Co-Director of UCSD/Salk Center for Academic Research and Training in Anthropogeny (CARTA) at UC San Diego, and Adjunct Professor at the Salk Institute. Varki was top-ranked throughout his education at Bishop Cotton Boys' School, Bangalore, and the Christian Medical College, Vellore. Following U.S. board certification in medicine, hematology, and oncology, he did a research fellowship with Stuart Kornfeld at Washington University in St. Louis, before joining the UCSD faculty in 1982. Varki is a Member of the U.S. National Academy of Medicine, the American Society for Clinical Investigation, and the Association of American Physicians. He is executive editor of the primary textbook, Essentials of Glycobiology. He served as Editor-in-Chief of the Journal of Clinical Investigation, President of the American Society for Clinical Investigation, and President of the Society for Glycobiology. He has received many honors, including the two highest in Glycobiology: the Karl Meyer Award and the International Glycoconjugate Organization Award. His published work has been cited almost 50,000 times, and his current research efforts focus on cell surface sugars called sialic acids and their roles in biology, evolution, and disease–particularly multiple differences between humans and our closest evolutionary cousins, which appear relevant to understanding distinct aspects of human biology and disease. Such interests led him to propose a novel Mind over Reality Transition theory about human origins, in the book DENIAL. He was elected a Fellow of the American Academy of Arts and Sciences in 2005.