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Simulating the Evolution of Aging

Patreon:   / primerlearning   Ageless book: https://ageless.link/ Andrew Steele on YT:    / @drandrewsteele   Papers and other further reading: Diversity of aging across the tree of life: https://pmc.ncbi.nlm.nih.gov/articles... Antagonistic pleiotropy and p53: https://pmc.ncbi.nlm.nih.gov/articles... An unsolved problem of biology (Medawar): https://ia903408.us.archive.org/31/it... Evolution of the mutation rate: https://pmc.ncbi.nlm.nih.gov/articles... Our World in Data Life Expectancy explainer: https://ourworldindata.org/life-expec... Other connections: Store: https://store.dftba.com/collections/p... Twitch:   / justin_helps   Discord:   / discord   Reddit:   / primerlearning   Bsky: https://bsky.app/profile/justinhelps.... Twitter:   / primerlearning   Made with Godot Github: https://github.com/Primer-Learning/Pr... Music by Mathieu Keith. For business inquiries: [email protected] 00:00 Introduction and outline 00:43 In which I beg for money 03:05 Simulation rules 04:09 Analyzing lifespans with no aging 09:19 Simple death genes 14:43 Mutation accumulation 26:58 Antagonistic pleiotropy 29:59 Review 30:21 Recommendations Made possible by support from these wonderful Patrons: abledbody Alba Caparros-Roissard Andrew Lang Brian Cloutier Captain Chinchilla Christoph Grabo Christy Serbus Daniel Rolandsgard Kjellevold Erik Broeders froginalog Gabriele Siino Garrett Greg m guguke Hank and Orin James Manning Jeff Jeremy Juan Benet Kairui Wang ketura Kevo Kieran Boulton Laura Reed Matthew Michal Maxim Nitsche Rebecca Wortham Ryan Mahuron Samu Kindler someonewhois81 Stevie Hryciw Will McCreary Zachariah Richard Fournier