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Turmeric dosage // How much turmeric should I take daily?

Turmeric Dosage // How much turmeric should I take daily? Turmeric is known for its vibrant yellow color and unbelievable health benefits. Interestingly, curcumin, the component of turmeric that gives turmeric its characteristic color, also happens to be the component credited for nearly all the health benefits of turmeric. Though estimates vary, it has been established that curcumin accounts for roughly 3-4% of the mass of turmeric. With curcumin in the spotlight, many supplement companies isolate and sell curcumin, ignoring the other components of the turmeric root. There is a bit of a problem, however. Curcumin is poorly absorbed and quickly metabolized. To combat this problem, many supplement producers also employ mechanisms to enhance the bioavailability of curcumin. The most common example is the addition of piperine, a component of black pepper that accounts for approximately 5% of black pepper’s mass. Research has demonstrated that the co-administration of 20 mg of piperine (or around 400 mg of black pepper) boosts the bioavailability of curcumin by 20X. However, this is merely the tip of the iceberg. Prasad et al. (2014) identified 46 different bioavailability-enhanced curcumin formulations. While bioavailability-enhancing mechanisms may represent a prime opportunity for supplement companies to establish a unique selling proposition, a good pharmacist would ask this question: Is it safe to take a spice like turmeric, known for its surprising health benefits, isolate the component credited for all the health benefits, administer that component in massive doses, and then boost that component’s availability in the bloodstream by 20X? Let’s try to find out. REFERENCES Cao J, Jia L, Zhou HM, Liu Y, Zhong LF. Mitochondrial and nuclear DNA damage induced by curcumin in human hepatoma G2 cells. Toxicol Sci. 2006;91(2):476-483. doi:10.1093/toxsci/kfj153 Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195-218. doi:10.1208/s12248-012-9432-8 Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-356. Cheng AL, Hsu CH, Lin JK, et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res. 2001;21(4B):2895-2900. Prasad S, Aggarwal BB. Turmeric, the Golden Spice: From Traditional Medicine to Modern Medicine. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 13. Available from: https://www.ncbi.nlm.nih.gov/books/NB... Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives – A review. J Tradit Complement Med. 2016;7(2):205-233. Published 2016 Jun 15. doi:10.1016/j.jtcme.2016.05.005 Uma Pradeep K, Geervani P, Eggum BO. Common Indian spices: nutrient composition, consumption and contribution to dietary value. Plant Foods Hum Nutr. 1993;44(2):137-148. doi:10.1007/BF01088378 Prasad S, Tyagi AK, Aggarwal BB. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat. 2014;46(1):2-18. Zhongfa L, Chiu M, Wang J, et al. Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer Chemother Pharmacol. 2012;69(3):679-689. doi:10.1007/s00280-011-1749-y Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451-458. Published 2014 Mar 20. doi:10.2147/CIA.S58535 Singhal S, Hasan N, Nirmal K, et al. Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials. 2021;22(1):105. Published 2021 Jan 30. doi:10.1186/s13063-021-05053-7 Haq IU, Imran M, Nadeem M, Tufail T, Gondal TA, Mubarak MS. Piperine: A review of its biological effects. Phytother Res. 2021;35(2):680-700. DISCLAIMER These videos have not been peer-reviewed. This content should not be used as medical advice, and must never replace the professional judgement of a licensed physician. All content on this channel is for educational purposes only.